For an oocyte to become All set for fertilization and development into an embryo, the proper list of genes needs to be turned on. Namekawa suspected that this pre-programming in the oocyte genome transpires in various stages — the 1st a single starting off round the time a female is born. He thought that chromatin remodeling proteins did Substantially of the get the job done, by shifting spools around.
“Our aim is to understand woman reproductive ageing, and why fertility quickly declines starting up inside the mid-30s,” claims Satoshi Namekawa, a professor of Microbiology and Molecular Genetics, in whose lab Munakata functions.
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By the time a human woman is born, her building ovaries now incorporate most of the egg cells, or “oocytes,” that she will ovulate in excess of the system of her reproductive lifestyle.
“We don’t know the way these cells are preserved for decades,” states Namekawa. “We need to know The key of this mechanism.
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This protein may “build and keep the chromatin state,” suggests Namekawa — retaining the spools set up plus the oocytes genetically primed given that the mouse matures.
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